MSX2 expression in the apical ectoderm ridge is regulated by an MSX2 and Dlx5 binding site.

@article{Pan2002MSX2EI,
  title={MSX2 expression in the apical ectoderm ridge is regulated by an MSX2 and Dlx5 binding site.},
  author={Z Pan and Mark S. Kronenberg and D Huang and Lauro Sumoy and Blanka Rogina and Alexander C. Lichtler and William B. Upholt},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={290 3},
  pages={955-61}
}
The apical ectodermal ridge (AER) is a specialized ectodermal region essential for limb outgrowth. Msx2 expression patterns in limb development strongly suggest an important role for Msx2 in the AER. Our previous studies identified a 348-bp fragment of the chicken Msx2 gene with AER enhancer activity. In this study, the functions of four potential homeodomain binding TAAT sites in this enhancer were studied using transgenic mice and in vitro protein-DNA interactions. Transgenic studies indicate… CONTINUE READING