MST4 kinase phosphorylates ACAP4 protein to orchestrate apical membrane remodeling during gastric acid secretion.

@article{Yuan2017MST4KP,
  title={MST4 kinase phosphorylates ACAP4 protein to orchestrate apical membrane remodeling during gastric acid secretion.},
  author={Xiao Yuan and Phil Y. Yao and Jiying Jiang and Yin Zhang and Zeqi Su and Wendy Y Yao and Xueying Wang and Ping Gui and McKay Mullen and Calmour Henry and Tarsha L Ward and Wenwen Wang and Larry Brako and Ruijun Tian and Xuannv Zhao and Fengsong Wang and Xinwang Cao and Dongmei Wang and Xing Liu and Xia Ding and Xuebiao Yao},
  journal={The Journal of biological chemistry},
  year={2017},
  volume={292 39},
  pages={16174-16187}
}
Digestion in the stomach depends on acidification of the lumen. Histamine-elicited acid secretion is triggered by activation of the PKA cascade, which ultimately results in the insertion of gastric H,K-ATPases into the apical plasma membranes of parietal cells. Our recent study revealed the functional role of PKA-MST4-ezrin signaling axis in histamine… CONTINUE READING