MST3 Kinase Phosphorylates TAO1/2 to Enable Myosin Va Function in Promoting Spine Synapse Development

@inproceedings{Ultanir2014MST3KP,
  title={MST3 Kinase Phosphorylates TAO1/2 to Enable Myosin Va Function in Promoting Spine Synapse Development},
  author={Sila K. Ultanir and Smita Yadav and Nicholas T. Hertz and Juan A Oses-Prieto and Suzanne Claxton and Alma L. Burlingame and Kevan M. Shokat and Lily Yeh Jan and Yuh-Nung Jan},
  booktitle={Neuron},
  year={2014}
}
Mammalian Sterile 20 (Ste20)-like kinase 3 (MST3) is a ubiquitously expressed kinase capable of enhancing axon outgrowth. Whether and how MST3 kinase signaling might regulate development of dendritic filopodia and spine synapses is unknown. Through shRNA-mediated depletion of MST3 and kinase-dead MST3 expression in developing hippocampal cultures, we found that MST3 is necessary for proper filopodia, dendritic spine, and excitatory synapse development. Knockdown of MST3 in layer 2/3 pyramidal… CONTINUE READING
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