MST1: a promising therapeutic target to restore functional beta cell mass in diabetes

@article{Ardestani2016MST1AP,
  title={MST1: a promising therapeutic target to restore functional beta cell mass in diabetes},
  author={Amin Ardestani and Kathrin Maedler},
  journal={Diabetologia},
  year={2016},
  volume={59},
  pages={1843-1849}
}
The loss of insulin-producing beta cells by apoptosis is a hallmark of all forms of diabetes mellitus. Strategies to prevent beta cell apoptosis and dysfunction are urgently needed to restore the insulin-producing cells and to prevent severe diabetes progression. We recently identified the serine/threonine kinase known as mammalian sterile 20-like kinase 1 (MST1) as a critical regulator of apoptotic beta cell death and dysfunction. MST1 activates several apoptotic signalling pathways, which… CONTINUE READING