MST1/MST2 Protein Kinases: Regulation and Physiologic Roles.

@article{Galan2016MST1MST2PK,
  title={MST1/MST2 Protein Kinases: Regulation and Physiologic Roles.},
  author={Jacob Anthony Galan and Joseph Avruch},
  journal={Biochemistry},
  year={2016},
  volume={55 39},
  pages={
          5507-5519
        }
}
The MST1 and MST2 protein kinases comprise the GCK-II subfamily of protein kinases. In addition to their amino-terminal kinase catalytic domain, related to that of the Saccharomyces cerevisiae protein kinase Ste20, their most characteristic feature is the presence near the carboxy terminus of a unique helical structure called a SARAH domain; this segment allows MST1/MST2 to homodimerize and to heterodimerize with the other polypeptides that contain SARAH domains, the noncatalytic polypeptides… CONTINUE READING
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