MSPocket: an orientation-independent algorithm for the detection of ligand binding pockets

@article{Zhu2011MSPocketAO,
  title={MSPocket: an orientation-independent algorithm for the detection of ligand binding pockets},
  author={Hongbo Zhu and M. Teresa Pisabarro},
  journal={Bioinformatics},
  year={2011},
  volume={27 3},
  pages={
          351-8
        }
}
MOTIVATION Identification of ligand binding pockets on proteins is crucial for the characterization of protein functions. It provides valuable information for protein-ligand docking and rational engineering of small molecules that regulate protein functions. A major number of current prediction algorithms of ligand binding pockets are based on cubic grid representation of proteins and, thus, the results are often protein orientation dependent. RESULTS We present the MSPocket program for… CONTINUE READING

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