MSP and GLP-1/Notch signaling coordinately regulate actomyosin-dependent cytoplasmic streaming and oocyte growth in C. elegans.

@article{Nadarajan2009MSPAG,
  title={MSP and GLP-1/Notch signaling coordinately regulate actomyosin-dependent cytoplasmic streaming and oocyte growth in C. elegans.},
  author={Saravanapriah Nadarajan and J. Amaranath Govindan and Marie McGovern and E. Jane Albert Hubbard and David Greenstein},
  journal={Development},
  year={2009},
  volume={136 13},
  pages={2223-34}
}
Fertility depends on germline stem cell proliferation, meiosis and gametogenesis, yet how these key transitions are coordinated is unclear. In C. elegans, we show that GLP-1/Notch signaling functions in the germline to modulate oocyte growth when sperm are available for fertilization and the major sperm protein (MSP) hormone is present. Reduction-of-function mutations in glp-1 cause oocytes to grow abnormally large when MSP is present and Galpha(s)-adenylate cyclase signaling in the gonadal… CONTINUE READING