MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling.

@article{Darragh2005MSKsAR,
  title={MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling.},
  author={Joanne Darragh and Ana Soloaga and Victoria A Beardmore and Andrew D Wingate and Giselle R Wiggin and Mark Peggie and J Simon C Arthur},
  journal={The Biochemical journal},
  year={2005},
  volume={390 Pt 3},
  pages={749-59}
}
MSK (mitogen- and stress-activated protein kinase) 1 and MSK2 are kinases activated downstream of either the ERK (extracellular-signal-regulated kinase) 1/2 or p38 MAPK (mitogen-activated protein kinase) pathways in vivo and are required for the phosphorylation of CREB (cAMP response element-binding protein) and histone H3. Here we show that the MSKs are involved in regulating the transcription of the immediate early gene Nur77. Stimulation of mouse embryonic fibroblasts with PMA, EGF… CONTINUE READING