MSI2 is required for maintaining activated myelodysplastic syndrome stem cells

  title={MSI2 is required for maintaining activated myelodysplastic syndrome stem cells},
  author={James Taggart and Tzu-Chieh Ho and Elianna M Amin and Haiming Xu and Trevor S. Barlowe and A. Hilda Ramirez Perez and Benjamin H. Durham and Patrick Tivnan and Rachel O. Okabe and Arthur Chow and Ly P. Vu and Sun Mi Park and Camila Prieto and Christopher Famulare and Minal Patel and Christopher Joachim Lengner and Amit Kumar Verma and Gail J. Roboz and Monica L Guzman and Virginia M. Klimek and Omar Abdel-Wahab and Christina S. Leslie and Stephen Nimer and Michael G Kharas},
  booktitle={Nature communications},
Myelodysplastic syndromes (MDS) are driven by complex genetic and epigenetic alterations. The MSI2 RNA-binding protein has been demonstrated to have a role in acute myeloid leukaemia and stem cell function, but its role in MDS is unknown. Here, we demonstrate that elevated MSI2 expression correlates with poor survival in MDS. Conditional deletion of Msi2 in a mouse model of MDS results in a rapid loss of MDS haematopoietic stem and progenitor cells (HSPCs) and reverses the clinical features of… CONTINUE READING
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