MSH3-Deficiency Initiates EMAST without Oncogenic Transformation of Human Colon Epithelial Cells

@inproceedings{Campregher2012MSH3DeficiencyIE,
  title={MSH3-Deficiency Initiates EMAST without Oncogenic Transformation of Human Colon Epithelial Cells},
  author={Christoph Campregher and Gerald Schmid and Franziska Ferk and Siegfried Knasm{\"u}ller and Vineeta Khare and Benedikt Kortuem and Kyle Dammann and Michaela Lang and Theresa Scharl and Andreas Spittler and Andres I. Roig and Jerry W Shay and Christopher Gerner and Christoph Gasch{\'e}},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND/AIM Elevated microsatellite instability at selected tetranucleotide repeats (EMAST) is a genetic signature in certain cases of sporadic colorectal cancer and has been linked to MSH3-deficiency. It is currently controversial whether EMAST is associated with oncogenic properties in humans, specifically as cancer development in Msh3-deficient mice is not enhanced. However, a mutator phenotype is different between species as the genetic positions of repetitive sequences are not conserved… CONTINUE READING
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