MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesis.

@article{Reitmair1996MSH2DC,
  title={MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesis.},
  author={Armin H Reitmair and Jian Chun Cai and Matthew Bjerknes and Mark Redston and Helen Cheng and Molly T. Pind and Karine Hay and Angela Mitri and Bharati Bapat and Tak W Mak and Steve Gallinger},
  journal={Cancer research},
  year={1996},
  volume={56 13},
  pages={2922-6}
}
Accelerated intestinal tumorigenesis is probable in hereditary nonpolyposis colorectal cancer, a condition associated with germ line DNA mismatch repair (MMR) gene defects, and is believed to be caused by rapid accumulation of replication errors in critical genes, such as the APC (adenomatous polyposis coli) tumor suppressor gene. To study the potential contribution of MMR genes to accelerated intestinal tumorigenesis, we crossed the Min mouse, heterozygous for a germ line mutation of Apc, with… CONTINUE READING

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