MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts.

@article{Burbelo1999MSE55AC,
  title={MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts.},
  author={Peter D. Burbelo and Diane M. Snow and W Bahou and Sarah Spiegel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 16},
  pages={9083-8}
}
Cdc42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization, kinase-signaling activation, and cell polarization. MSE55 is a nonkinase CRIB (Cdc42/Rac interactive-binding) domain-containing molecule of unknown function. Using glutathione S-transferase-capture experiments, we show that MSE55 binds to Cdc42 in a GTP-dependent manner. MSE55 binding to Cdc42 required an intact CRIB domain, because a MSE55 CRIB domain mutant no longer… CONTINUE READING