MSCs modified with ACE2 restore endothelial function following LPS challenge by inhibiting the activation of RAS.

Abstract

Angiotensin (Ang) II plays an important role in the process of endothelial dysfunction in acute lung injury (ALI) and is degraded by angiotensin-converting enzyme2 (ACE2). However, treatments that target ACE2 to injured endothelium and promote endothelial repair of ALI are lacking. Mesenchymal stem cells (MSCs) are capable of homing to the injured site and… (More)
DOI: 10.1002/jcp.24794

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@article{He2015MSCsMW, title={MSCs modified with ACE2 restore endothelial function following LPS challenge by inhibiting the activation of RAS.}, author={Hong-li He and Ling Liu and Qi-hong Chen and Shi-xia Cai and Ji-bin Han and Shu-ling Hu and Pan Chun and Yi Yang and Feng-mei Guo and Ying-zi Huang and Hai-bo Qiu}, journal={Journal of cellular physiology}, year={2015}, volume={230 3}, pages={691-701} }