MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus.

@article{Liu2015MSCTI,
  title={MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus.},
  author={S. Liu and Dawei Liu and C. Chen and K. Hamamura and A. Moshaverinia and R. Yang and Y. Liu and Y. Jin and S. Shi},
  journal={Cell metabolism},
  year={2015},
  volume={22 4},
  pages={
          606-18
        }
}
  • S. Liu, Dawei Liu, +6 authors S. Shi
  • Published 2015
  • Biology, Medicine
  • Cell metabolism
  • Mesenchymal stem cell transplantation (MSCT) has been used to treat human diseases, but the detailed mechanisms underlying its success are not fully understood. Here we show that MSCT rescues bone marrow MSC (BMMSC) function and ameliorates osteopenia in Fas-deficient-MRL/lpr mice. Mechanistically, we show that Fas deficiency causes failure of miR-29b release, thereby elevating intracellular miR-29b levels, and downregulates DNA methyltransferase 1 (Dnmt1) expression in MRL/lpr BMMSCs. This… CONTINUE READING
    110 Citations
    Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors
    • 27
    • PDF
    Alkaline Phosphatase Controls Lineage Switching of Mesenchymal Stem Cells by Regulating the LRP6/GSK3β Complex in Hypophosphatasia
    • 8
    • PDF
    Alpl prevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells
    • 21
    • PDF
    Stem cell-based bone regeneration in diseased microenvironments: Challenges and solutions.
    • 39
    • PDF
    BM-MSC-derived exosomes alleviate radiation-induced bone loss by restoring the function of recipient BM-MSCs and activating Wnt/β-catenin signaling
    • 31
    Additive Therapeutic Effects of Mesenchymal Stem Cells and IL-37 for Systemic Lupus Erythematosus.
    • 8
    Allogeneic Mesenchymal Stem Cell Therapy Promotes Osteoblastogenesis and Prevents Glucocorticoid‐Induced Osteoporosis
    • B. Sui, C. Hu, +7 authors Y. Jin
    • Biology, Medicine
    • Stem cells translational medicine
    • 2016
    • 43

    References

    SHOWING 1-10 OF 55 REFERENCES
    Mesenchymal Stem Cell Transplantation Reverses Multiorgan Dysfunction in Systemic Lupus Erythematosus Mice and Humans
    • 474
    Mesenchymal stem cells: a double-edged sword in regulating immune responses
    • 242
    • PDF
    Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis.
    • 424
    Concise Review: MicroRNA Function in Multipotent Mesenchymal Stromal Cells
    • 96
    MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation.
    • 220
    • PDF
    Concise Review: Mesenchymal Stem Cells and Translational Medicine: Emerging Issues
    • 260
    Mesenchymal Stem Cell-Based Tissue Regeneration is Governed by Recipient T Lymphocyte via IFN-γ and TNF-α
    • 415
    Transplantation of bone marrow cells reduces CCl4‐induced liver fibrosis in mice
    • 505
    Allogeneic Mesenchymal Stem Cell Transplantation in Severe and Refractory Systemic Lupus Erythematosus: 4 Years of Experience
    • 181
    • PDF
    Bone Marrow Mesenchymal Stem Cells Stimulate Cardiac Stem Cell Proliferation and Differentiation
    • 631