MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus.

  title={MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus.},
  author={S. Liu and Dawei Liu and C. Chen and K. Hamamura and A. Moshaverinia and R. Yang and Y. Liu and Y. Jin and S. Shi},
  journal={Cell metabolism},
  volume={22 4},
  • S. Liu, Dawei Liu, +6 authors S. Shi
  • Published 2015
  • Biology, Medicine
  • Cell metabolism
  • Mesenchymal stem cell transplantation (MSCT) has been used to treat human diseases, but the detailed mechanisms underlying its success are not fully understood. Here we show that MSCT rescues bone marrow MSC (BMMSC) function and ameliorates osteopenia in Fas-deficient-MRL/lpr mice. Mechanistically, we show that Fas deficiency causes failure of miR-29b release, thereby elevating intracellular miR-29b levels, and downregulates DNA methyltransferase 1 (Dnmt1) expression in MRL/lpr BMMSCs. This… CONTINUE READING
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