MSARI: multiple sequence alignments for statistical detection of RNA secondary structure.

  title={MSARI: multiple sequence alignments for statistical detection of RNA secondary structure.},
  author={A. F. Coventry and Daniel J. Kleitman and Bonnie Berger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 33},
We present a highly accurate method for identifying genes with conserved RNA secondary structure by searching multiple sequence alignments of a large set of candidate orthologs for correlated arrangements of reverse-complementary regions. This approach is growing increasingly feasible as the genomes of ever more organisms are sequenced. A program called msari implements this method and is significantly more accurate than existing methods in the context of automatically generated alignments… CONTINUE READING
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Bayesian Data Analysis (Chapman & Hall, London)

  • A. Gelman, J. Carlin, H. Stern, D. Rubin
  • 2004

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