MSARC: Multiple sequence alignment by residue clustering

@article{Modzelewski2013MSARCMS,
  title={MSARC: Multiple sequence alignment by residue clustering},
  author={Michal Modzelewski and Norbert Dojer},
  journal={Algorithms for Molecular Biology : AMB},
  year={2013},
  volume={9},
  pages={12 - 12}
}
  • Michal Modzelewski, Norbert Dojer
  • Published 2013
  • Biology, Computer Science, Mathematics, Medicine
  • Algorithms for Molecular Biology : AMB
  • BackgroundProgressive methods offer efficient and reasonably good solutions to the multiple sequence alignment problem. However, resulting alignments are biased by guide-trees, especially for relatively distant sequences.ResultsWe propose MSARC, a new graph-clustering based algorithm that aligns sequence sets without guide-trees. Experiments on the BAliBASE dataset show that MSARC achieves alignment quality similar to the best progressive methods.Furthermore, MSARC outperforms them on sequence… CONTINUE READING
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