MS4A4B is a GITR-associated membrane adapter, expressed by regulatory T cells, which modulates T cell activation.

@article{Howie2009MS4A4BIA,
  title={MS4A4B is a GITR-associated membrane adapter, expressed by regulatory T cells, which modulates T cell activation.},
  author={Duncan Howie and Kathleen F. Nolan and Stephen R Daley and Emma Damon Butterfield and Elizabeth Adams and Hugo Garcia-Rueda and Claire Thompson and Nigel J. Saunders and Stephen Paul Cobbold and Yukiko Tone and Masahide Tone and Herman Waldmann},
  journal={Journal of immunology},
  year={2009},
  volume={183 7},
  pages={4197-204}
}
In the aftermath of thymic negative selection, natural and adaptive regulatory T cells (Tregs) must acknowledge peripheral, "danger-free" self-Ag to ensure their sustained activity. In this paper, we show that natural and adaptive Tregs or T cells transduced with cDNA for Foxp3, just like Th1 cells, express members of the MS4A family of transmembrane molecules. Naive T cells transduced with MS4A4B become able to respond to lower levels of Ag. Using two family members, MS4A4B and MS4A6B, as… CONTINUE READING

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