MS4: Multiscale Modeling in Cancer: From Genotype to Phenotype I Nonlinear Networks Dynamics and Opposite Effects of Wnt5a on Motility in Melanomas

Abstract

Understanding how networks react to molecular targeting is important in biological sciences and medicine. Here, we encounter unusual nonlinear dynamics after targeting of Wnt5a, which enhances motility in 3/5 melanoma cell lines and represses motility in the other two. To explain this behavior we develop an optimization-driven general method for recovering… (More)

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