MS2 VLP-based delivery of microRNA-146a inhibits autoantibody production in lupus-prone mice

@inproceedings{Pan2012MS2VD,
  title={MS2 VLP-based delivery of microRNA-146a inhibits autoantibody production in lupus-prone mice},
  author={Yang Pan and Tingting Jia and Ying Zhang and Kuo Zhang and Rui Zhang and Jinming Li and Lunan Wang},
  booktitle={International journal of nanomedicine},
  year={2012}
}
BACKGROUND Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of pathogenic autoantibodies. Recent studies suggest that microRNAs (miRNAs) play an essential role in immunoregulation and may be involved in the pathogenesis of SLE. Therefore, it was of interest to investigate the potential therapeutic application of miRNAs in SLE, a concept that has not been thoroughly investigated thus far. Virus-like particles (VLPs) are a type of recombinant… CONTINUE READING

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