MS-818 accelerates mobilization of endothelial progenitor cells and differentiation to endothelial cells.

@article{Kanemura2004MS818AM,
  title={MS-818 accelerates mobilization of endothelial progenitor cells and differentiation to endothelial cells.},
  author={Masanori Kanemura and Mayumi Abe and Masatsugu Ueda and Minoru Ueki and Akira Awaya and Yasufumi Sato},
  journal={Endothelium : journal of endothelial cell research},
  year={2004},
  volume={11 5-6},
  pages={221-30}
}
MS-818 that is a synthetic pyrimidine compound and shown to have neurotrophic actions, enhanced basic fibroblast growth factor (bFGF)-induced angiogenesis in vivo. However, the mechanism and whether MS-818 affects endothelial cells (ECs) directly is not known. Here, the authors investigated whether MS-818 alone could induce angiogenesis and tried to clarify the mechanism of neovascularization by MS-818 in terms of angiogenesis and vasculogenesis. The authors show that MS-818 affects ECs… CONTINUE READING