MS-271, a novel inhibitor of calmodulin-activated myosin light chain kinase from Streptomyces sp.--I. Isolation, structural determination and biological properties of MS-271.

@article{Yano1996MS271AN,
  title={MS-271, a novel inhibitor of calmodulin-activated myosin light chain kinase from Streptomyces sp.--I. Isolation, structural determination and biological properties of MS-271.},
  author={Kazuhisa Yano and Shima Toki and Satoshi Nakanishi and Keiko Ochiai and Katsuhiko Ando and Maki Yoshida and Yuzuru Matsuda and Motoo Yamasaki},
  journal={Bioorganic & medicinal chemistry},
  year={1996},
  volume={4 1},
  pages={115-20}
}
A novel cyclic peptide, MS-271, was isolated from the culture broth of an actinomycete, Streptomyces sp. M-271 as an inhibitor of smooth muscle myosin light chain kinase (MLCK). MS-271 inhibited the MLCK from chicken gizzard with an IC50 value of 8 microM. MS-271 did not inhibit cyclic AMP-dependent protein kinase, protein kinase C or calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase at concentrations up to 400 microM. The primary structure of MS-271 was identical to that of… CONTINUE READING

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