MS-1020 is a novel small molecule that selectively inhibits JAK3 activity.

  title={MS-1020 is a novel small molecule that selectively inhibits JAK3 activity.},
  author={B Kim and Sei-Ryang Oh and Chang-Hong Yin and Sangku Lee and E Kim and Min-seok Kim and Claudio Sandoval and Somasundaram Jayabose and Erika A Bach and Hyeong-Kyu Lee and G Baeg},
  journal={British journal of haematology},
  volume={148 1},
In order to identify Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling inhibitors, a cell-based high throughput screening was performed using a plant extract library that identified Nb-(alpha-hydroxynaphthoyl)serotonin called MS-1020 as a novel JAK3 inhibitor. MS-1020 potently inhibited persistently-active STAT3 in a cell type-specific manner. Further examination showed that MS-1020 selectively blocked constitutively-active JAK3 and consistently suppressed… CONTINUE READING
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