MS/MS approach for characterization of the fatty acid distribution on mycobacterial phosphatidyl-myo-inositol mannosides.

@article{Gilleron2006MSMSAF,
  title={MS/MS approach for characterization of the fatty acid distribution on mycobacterial phosphatidyl-myo-inositol mannosides.},
  author={Martine Gilleron and Buko Lindner and Germain Puzo},
  journal={Analytical chemistry},
  year={2006},
  volume={78 24},
  pages={8543-8}
}
Phosphatidyl-myo-inositol mannosides (PIM) are not only important structural components of the mycobacterial envelope but also are major non-peptidic antigens of the host innate and acquired immune responses. Indeed, they are ligands of TLR-2 and they activate CD1-restricted T lymphocytes. In addition, PIM constitute the basic structure of the lipidic anchor of two lipoglycans, lipomannans and lipoarabinomannans, which are important immunomodulators in the course of tuberculosis. The fatty acyl… CONTINUE READING

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