MRSI correlates of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder.

@article{ONeill2012MRSICO,
  title={MRSI correlates of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder.},
  author={Joseph O'Neill and John C. Piacentini and Susanna Chang and Jennifer G. Levitt and Michelle S Rozenman and Lindsey Bergman and Noriko Salamon and Jeffry R. Alger and James Mccracken},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2012},
  volume={36 1},
  pages={161-8}
}
BACKGROUND The brain mechanisms of cognitive-behavioral therapy (CBT), a highly effective treatment for pediatric obsessive-compulsive disorder (OCD), are unknown. Neuroimaging in adult OCD indicates that CBT is associated with metabolic changes in striatum, thalamus, and anterior cingulate cortex. We therefore probed putative metabolic effects of CBT on these brain structures in pediatric OCD using proton magnetic resonance spectroscopic imaging (1H MRSI). METHOD Five unmedicated OCD… CONTINUE READING