Corpus ID: 82146322

MRS evaluations of the metabolic response of human leukemia cells to a new tyrosine kinase inhibitor gleevec

@inproceedings{Gottschalk2002MRSEO,
  title={MRS evaluations of the metabolic response of human leukemia cells to a new tyrosine kinase inhibitor gleevec},
  author={S. Gottschalk and C MiljusMBenetLzChristiansULeibfritzDHainz and N. Serkova},
  year={2002}
}
The new antiproliferative agent Gleevec inhibits bcr/abl tyrosine kinase in chronic myeloid leukemia. It was our goal to assess the metabolic response of human leukemia cells to exposure to gleevec using MRS of cell extracts. Gleevec inhibited cell growth of the bcr/abl positive, but not of the bcr/abl negative cells. Gleevec led to a specific inhibition of glycolitic activity with the subsequent stimulation of the Krebs cycle in the bcr/abl positive cells. Since the energy metabolism was… CONTINUE READING