MRP6 (ABCC6) Detection in Normal Human Tissues and Tumors

  title={MRP6 (ABCC6) Detection in Normal Human Tissues and Tumors},
  author={George L. Scheffer and Xiaofeng Hu and Adriana C. L. M. Pijnenborg and Jan Wijnholds and Arthur A. B. Bergen and Rik J. Scheper},
  journal={Laboratory Investigation},
M RP6 (ABCC6) is a member of the subfamily of the multidrug resistance proteins (MRPs, reviewed by Borst et al, 2000), but its putative role in multidrug resistance (MDR, reviewed by Moscow et al, 1997) is still under investigation. Closely related proteins such as MDR1 P-glycoprotein (P-gp, ABCB1, reviewed by Ambudkar et al, 1999), breast cancer resistance protein (BCRP, ABCG2; Doyle et al, 1998), and MRP1, -2, and -3 (ABCC1–3) are established MDR transporters. The exact range of substrates… CONTINUE READING


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