MRP2 and GSTP1 polymorphisms and chemotherapy response in advanced non-small cell lung cancer

@article{Sun2009MRP2AG,
  title={MRP2 and GSTP1 polymorphisms and chemotherapy response in advanced non-small cell lung cancer},
  author={Ning Sun and Xinchen Sun and Baoan Chen and Hongyan Cheng and Jifeng Feng and L O Cheng and Zuhong Lu},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2009},
  volume={65},
  pages={437 - 446}
}
The level of drug metabolism and drug transport is correlated with the sensitivity of cancer cells towards platinum-based chemotherapy. We hypothesize that genetic polymorphisms in metabolising enzymes gene GSTP1 (glutathione S-transferase P1), and MRP2 (multidrug resistance-associated protein 2) (ABCC2), which result in inter-individual differences in metabolism and drug disposition, may predict clinical response to platinum agents in advanced non-small cell lung cancer (NSCLC) patients… CONTINUE READING