MRP and MDR1 gene expression in primary breast carcinomas.

  title={MRP and MDR1 gene expression in primary breast carcinomas.},
  author={Martin Filipits and R. W. Suchomel and Gerhard Dekan and Karin Haider and Gunnar Valdimarsson and Dieter Depisch and Robert Pirker},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={2 7},
To evaluate the clinically important mechanisms of drug resistance in breast cancer, the expression of the MRP gene and the corresponding one for the MDR1 gene were determined in primary breast carcinoma specimens by both reverse transcription-PCR (n = 134) and immunohistochemistry (n = 63). Expression of MRP RNA was observed in all breast cancer specimens. MDR1 RNA was detected in 80 (60%) of the carcinomas. Staining with monoclonal antibodies QCRL-1 and QCRL-3, which both recognize MRP, was… CONTINUE READING
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