MROH7‐TTC4 read‐through lncRNA suppresses vascular endothelial cell apoptosis and is upregulated by inhibition of ANXA7 GTPase activity

@article{He2019MROH7TTC4RL,
  title={MROH7‐TTC4 read‐through lncRNA suppresses vascular endothelial cell apoptosis and is upregulated by inhibition of ANXA7 GTPase activity},
  author={X. He and X. Zhao and L. Sự and B. Zhao and J. Miao},
  journal={The FEBS Journal},
  year={2019},
  volume={286}
}
  • X. He, X. Zhao, +2 authors J. Miao
  • Published 2019
  • Chemistry, Medicine
  • The FEBS Journal
  • Apoptosis of vascular endothelial cells (VEC) is the main form of vascular injury that is closely linked to numerous cardiovascular diseases. Therefore, it is important to find new factors that can suppress VEC apoptosis. By using long noncoding RNA (lncRNA) microarray analysis, we found a new read‐through lncRNA, MROH7‐TTC4, which acted as an apoptosis inhibitor in VECs. Furthermore, by using the inhibitor (ABO) of annexin A7 (ANXA7) GTPase, we discovered that ANXA7 translocated into nucleus… CONTINUE READING
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