MROH7‐TTC4 read‐through lncRNA suppresses vascular endothelial cell apoptosis and is upregulated by inhibition of ANXA7 GTPase activity
@article{He2019MROH7TTC4RL, title={MROH7‐TTC4 read‐through lncRNA suppresses vascular endothelial cell apoptosis and is upregulated by inhibition of ANXA7 GTPase activity}, author={X. He and X. Zhao and L. Sự and B. Zhao and J. Miao}, journal={The FEBS Journal}, year={2019}, volume={286} }
Apoptosis of vascular endothelial cells (VEC) is the main form of vascular injury that is closely linked to numerous cardiovascular diseases. Therefore, it is important to find new factors that can suppress VEC apoptosis. By using long noncoding RNA (lncRNA) microarray analysis, we found a new read‐through lncRNA, MROH7‐TTC4, which acted as an apoptosis inhibitor in VECs. Furthermore, by using the inhibitor (ABO) of annexin A7 (ANXA7) GTPase, we discovered that ANXA7 translocated into nucleus… CONTINUE READING
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References
SHOWING 1-10 OF 37 REFERENCES
Long Noncoding RNA LOC100129973 Suppresses Apoptosis by Targeting miR-4707-5p and miR-4767 in Vascular Endothelial Cells
- Biology, Medicine
- Scientific reports
- 2016
- 43
- PDF
A new microRNA signal pathway regulated by long noncoding RNA TGFB2-OT1 in autophagy and inflammation of vascular endothelial cells
- Biology, Medicine
- Autophagy
- 2015
- 93
TIA1 interacts with annexin A7 in regulating vascular endothelial cell autophagy.
- Chemistry, Medicine
- The international journal of biochemistry & cell biology
- 2014
- 16
The c-Myc-regulated lncRNA NEAT1 and paraspeckles modulate imatinib-induced apoptosis in CML cells
- Biology, Medicine
- Molecular Cancer
- 2018
- 42
Targeting annexin A7 by a small molecule suppressed the activity of phosphatidylcholine-specific phospholipase C in vascular endothelial cells and inhibited atherosclerosis in apolipoprotein E−/− mice
- Biology, Medicine
- Cell Death and Disease
- 2013
- 28
- PDF
Overexpression of KLHL23 protein from read‐through transcription of PHOSPHO2‐KLHL23 in gastric cancer increases cell proliferation
- Biology, Medicine
- FEBS open bio
- 2016
- 5
Relationship between annexin A7 and integrin β4 in autophagy.
- Chemistry, Medicine
- The international journal of biochemistry & cell biology
- 2013
- 12