MROH7‐TTC4 read‐through lncRNA suppresses vascular endothelial cell apoptosis and is upregulated by inhibition of ANXA7 GTPase activity

@article{He2019MROH7TTC4RL,
  title={MROH7‐TTC4 read‐through lncRNA suppresses vascular endothelial cell apoptosis and is upregulated by inhibition of ANXA7 GTPase activity},
  author={Xiaoying He and Xuan Zhao and Le Su and Baoxiang Zhao and Junying Miao},
  journal={The FEBS Journal},
  year={2019},
  volume={286}
}
Apoptosis of vascular endothelial cells (VEC) is the main form of vascular injury that is closely linked to numerous cardiovascular diseases. Therefore, it is important to find new factors that can suppress VEC apoptosis. By using long noncoding RNA (lncRNA) microarray analysis, we found a new read‐through lncRNA, MROH7‐TTC4, which acted as an apoptosis inhibitor in VECs. Furthermore, by using the inhibitor (ABO) of annexin A7 (ANXA7) GTPase, we discovered that ANXA7 translocated into nucleus… 
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5 Citations

5 Citations

Promoting TTC4 and HSP70 interaction and translocation of annexin A7 to lysosome inhibits apoptosis in vascular endothelial cells
  • Xiaoying He, Zhao-Min Lin, J. Miao
  • Biology, Chemistry
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2020
TLDR
A special mechanism by which TTC4 inhibited apoptosis via HSP70 in VECs was discovered, on the one hand, increasing TTC4 and H SP70 interaction upregulated Akt that inhibition of apoptosis was increased, and on the other hand, decreasingHSP70 and ANXA7 interaction promoted the translocation of ANXa7 to lysosome, which inhibited apoptotic through protecting the lysOSomal membrane stability.
LncRNA MIR497HG inhibits proliferation and migration of retinal endothelial cells under high-level glucose treatment via miRNA-128-3p/SIRT1 axis.
TLDR
MIR497HG is downregulated after HG treatment, and it suppresses the proliferation and migration of HRECs by targeting miRNA-128-3p/SIRT1 axis, thus influencing the progression of diabetic retinopathy.
Long Noncoding RNAs Coregulated by Annexin A7 and JNK in Hepatocellular Carcinoma Cells Identified by Whole-Genome Expression Profiling
TLDR
These lncRNAs are intriguing candidate targets for mechanistic analysis of HCC progression and therapeutic intervention and selected 4 of these for verification based on putative involvement in cancer regulation according to GO and KEEG analyses of target genes.
Emerging role of long non-coding RNAs in endothelial dysfunction and their molecular mechanisms.
Annexin A Protein Family in Atherosclerosis.

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