MRM-based multiplexed quantitation of 67 putative cardiovascular disease biomarkers in human plasma.

@article{Domanski2012MRMbasedMQ,
  title={MRM-based multiplexed quantitation of 67 putative cardiovascular disease biomarkers in human plasma.},
  author={Dominik Domanski and Andrew J. Percy and Juncong Yang and Andrew G. Chambers and John Stuart Hill and Gabriela V. Cohen Freue and Christoph H. Borchers},
  journal={Proteomics},
  year={2012},
  volume={12 8},
  pages={
          1222-43
        }
}
A highly-multiplexed MRM-based assay for determination of cardiovascular disease (CVD) status and disease classification has been developed for clinical research. A high-flow system using ultra-high performance LC and an Agilent 6490 triple quadrupole mass spectrometer, equipped with an ion funnel, provided ease of use and increased the robustness of the assay. The assay uses 135 stable isotope-labeled peptide standards for the quantitation of 67 putative biomarkers of CVD in tryptic digests of… CONTINUE READING

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