MRL mice fail to heal the heart in response to ischemia‐reperfusion injury

@article{Abdullah2005MRLMF,
  title={MRL mice fail to heal the heart in response to ischemia‐reperfusion injury},
  author={I. Abdullah and J. Lepore and J. Epstein and M. Parmacek and P. Gruber},
  journal={Wound Repair and Regeneration},
  year={2005},
  volume={13}
}
The MRL/MpJ mouse strain has been reported to recover after right ventricular cryoinjury without scar formation or evidence of ventricular dysfunction, suggesting that this mouse strain harbors genetic traits that confer the capacity for adult myocardium to regenerate. We therefore sought to assess the capacity of adult MRL myocardium to regenerate in a left ventricular ischemia‐reperfusion model of myocardial infarction, which more closely recapitulates injury that occurs in human disease. MRL… Expand
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1
2
3
4
...

References

SHOWING 1-10 OF 19 REFERENCES
Heart regeneration in adult MRL mice
  • John M. Leferovich, Khamilia Bedelbaeva, +4 authors Ellen Heber-Katz
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
Scar formation after ischemic myocardial injury in MRL mice.
Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
Varying susceptibility to myocardial infarction among C57BL/6 mice of different genetic background.
Heart Regeneration in Zebrafish
...
1
2
...