MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death.

Abstract

Activation of the cascade of proteolytic caspases has been identified as the final common pathway of apoptosis in diverse biological systems. We have isolated a gene, termed MRIT, that possesses overall sequence homology to FLICE (MACH), a large prodomain caspase that links the aggregated complex of the death domain receptors of the tumor necrosis factor… (More)

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