MRI signal hyperintensities and failure to remit following antidepressant treatment.

@article{Sneed2011MRISH,
  title={MRI signal hyperintensities and failure to remit following antidepressant treatment.},
  author={Joel R. Sneed and Michelle E Culang-Reinlieb and Adam M. Brickman and Faith M. Gunning-Dixon and Lauren C Johnert and Ernst Garcon and S P Steven P Roose},
  journal={Journal of affective disorders},
  year={2011},
  volume={135 1-3},
  pages={315-20}
}
BACKGROUND MRI signal hyperintensities predict poor remission to antidepressant treatment. Previous studies using volumetrics in outpatient samples have relied on total lesion volume. The purpose of this study was to test whether remission from geriatric depression depends on lesion volume by region of interest (ROI). METHOD Thirty-eight patients received baseline MRIs as part of a larger 12-week, randomized clinical trial comparing sertraline and nortriptyline in the treatment of late-life… CONTINUE READING

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