MRI measurements of tumor size and pharmacokinetic parameters as early predictors of response in breast cancer patients undergoing neoadjuvant anthracycline chemotherapy.

@article{Yu2007MRIMO,
  title={MRI measurements of tumor size and pharmacokinetic parameters as early predictors of response in breast cancer patients undergoing neoadjuvant anthracycline chemotherapy.},
  author={Hon J. Yu and Jeon-Hor Chen and Rita S. Mehta and Orhan Nalcioglu and Min-Ying Su},
  journal={Journal of magnetic resonance imaging : JMRI},
  year={2007},
  volume={26 3},
  pages={
          615-23
        }
}
PURPOSE To investigate the value of using changes in three parameters (tumor size, transfer constant (K(trans)), and rate constant (k(ep))) obtained after the first treatment-cycle in predicting the final clinical response after two to four cycles of neoadjuvant anthracycline and cyclophosphamide (AC) chemotherapy. MATERIALS AND METHODS Early changes in the three parameters were measured in 29 patients with invasive breast cancer by MRI after one cycle of treatment. Changes were then assessed… CONTINUE READING
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