MRI heralds secondary nigral lesion after brain ischemia in mice: a secondary time window for neuroprotection.

Abstract

Cerebral ischemia in the territory of the middle cerebral artery (MCA) can induce delayed neuronal cell death in the ipsilateral substantia nigra (SN) remote from the primary ischemic lesion. This exofocal postischemic neuronal degeneration (EPND) may worsen stroke outcomes. However, the mechanisms leading to EPND are poorly understood. Here, we studied the… (More)
DOI: 10.1038/jcbfm.2015.153

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