MRI-guided focused ultrasound surgery.

  title={MRI-guided focused ultrasound surgery.},
  author={Ferenc A. Jolesz},
  journal={Annual review of medicine},
  • F. Jolesz
  • Published 26 September 2007
  • Medicine
  • Annual review of medicine
MRI-guided focused ultrasound (MRgFUS) surgery is a noninvasive thermal ablation method that uses magnetic resonance imaging (MRI) for target definition, treatment planning, and closed-loop control of energy deposition. Integrating FUS and MRI as a therapy delivery system allows us to localize, target, and monitor in real time, and thus to ablate targeted tissue without damaging normal structures. This precision makes MRgFUS an attractive alternative to surgical resection or radiation therapy… 
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The most promising application for MRgFUS will be in the brain, and they are thermal ablations for brain tumors and functional neurosurgery, and nonthermal, nonablative uses for disruption of the blood-brain barrier or blood clot and hematoma dissolution by liquification as well as the promising application of neuromodulation.
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Key developments, the current status, and the potential of tcMRIgFUS for neurological applications are presented, and important issues for ongoing research are delineated.
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Magnetic resonance-guided focused ultrasound surgery (MRgFUS) of the brain can be expected to revolutionize central nervous system (CNS) disease treatment and change the treatment paradigm in
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This paper reviews some significant developments reported in the literature related to the image-based control of the FUS therapy for kidney, breast, prostate, and brain, including the own experience of the authors on the active feedback Control of the temperature during FUS ablation.
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MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: a feasibility study.
MR imaging-guided FUS can be performed to noninvasively coagulate benign breast fibroadenomas and improve thermal imaging sequences over the treatment period, with 82% (279 of 342) of the hot spots visible in the last seven treatments.
Focused US system for MR imaging-guided tumor ablation.
MR imaging provides target definition and control for thermal therapy in regions of variable perfusion or in tissues that are not well characterized in patients with tumor-guided tumor ablation.
Magnetic resonance guidance for radiofrequency ablation of liver tumors
The role of MR guidance for RF ablation of liver tumors is summarized, which offers the possibility for a safe and effective therapy option in the treatment of primary and secondary hepatic malignancies.
MR-guided focused ultrasound surgery.
A thermal analysis of focused ultrasound provides an estimate of the time-dependent temperature distribution and thermal dose required for ultrasound surgery and shows that above a critical thermal dose, the in vitro tissue was irreversibly altered and the focal lesion was observed on both the MR image and the specimen slice.
Spatio-Temporal Control of Gene Expression and Cancer Treatment Using Magnetic Resonance Imaging–Guided Focused Ultrasound
  • C. Moonen
  • Medicine, Physics
    Clinical Cancer Research
  • 2007
The primary purpose of the development of MRI-guided HIFU was to achieve safe noninvasive tissue ablation and the technique has been tested extensively in preclinical studies and is now accepted in the clinic for ablation of uterine fibroids.
Magnetic resonance image-guided thermal ablations.
MRI is sensitive to thermally induced tissue changes resulting from the therapies, giving the physician a method to determine the success or failure of the treatment.
MR imaging-guided focused US ablation of breast cancer: histopathologic assessment of effectiveness-- initial experience.
Thermal coagulation of small breast tumors by means of MR imaging-guided focused US appears to be a promising noninvasive ablation procedure.