MRI evaluation of asymmetry of nigrostriatal damage in the early stage of early-onset Parkinson's disease.

  title={MRI evaluation of asymmetry of nigrostriatal damage in the early stage of early-onset Parkinson's disease.},
  author={J. Wang and Q. Yang and X. Sun and Jeffrey Vesek and Zachary Mosher and M. Vasavada and J. Chu and S. Kanekar and V. Shivkumar and K. Venkiteswaran and T. Subramanian},
  journal={Parkinsonism & related disorders},
  volume={21 6},
  • J. Wang, Q. Yang, +8 authors T. Subramanian
  • Published 2015
  • Medicine, Psychology
  • Parkinsonism & related disorders
  • INTRODUCTION The motor symptoms and signs of early-onset idiopathic Parkinson's disease (PD) in Hoehn and Yahr (H&Y) stage-1 are generally unilateral. We hypothesized that there would be detectable differences in the quantitative MRI parameters in these PD patients between the hemispheres contralateral to the clinically symptomatic and non-symptomatic body side. METHODS We tested this hypothesis by comparing transverse relaxation rates and diffusion tensor imaging (DTI) parameters in the… CONTINUE READING
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