MRI estimates of brain iron concentration in normal aging: Comparison of field-dependent (FDRI) and phase (SWI) methods

@article{Pfefferbaum2009MRIEO,
  title={MRI estimates of brain iron concentration in normal aging: Comparison of field-dependent (FDRI) and phase (SWI) methods},
  author={Adolf Pfefferbaum and Elfar Adalsteinsson and Torsten Rohlfing and Edith V. Sullivan},
  journal={NeuroImage},
  year={2009},
  volume={47},
  pages={493-500}
}
Different brain structures accumulate iron at different rates throughout the adult life span. Typically, striatal and brain stem structures are higher in iron concentrations in older than younger adults, whereas cortical white matter and thalamus have lower concentrations in the elderly than young adults. Brain iron can be measured in vivo with MRI by estimating the relaxivity increase across magnetic field strengths, which yields the Field-Dependent Relaxation Rate Increase (FDRI) metric. The… CONTINUE READING
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