MRI detection of secondary damage after stroke: chronic iron accumulation in the thalamus of the rat brain.

@article{Justicia2008MRIDO,
  title={MRI detection of secondary damage after stroke: chronic iron accumulation in the thalamus of the rat brain.},
  author={Carles Justicia and Pedro Ramos-Cabrer and Mathias Hoehn},
  journal={Stroke},
  year={2008},
  volume={39 5},
  pages={1541-7}
}
BACKGROUND AND PURPOSE Iron plays a central role in many metabolic processes. Under certain pathological situations it accumulates, producing negative effects such as increasing damage by oxidative stress. The present study examined long-term iron accumulation in a stroke model with secondary degeneration, using MRI and histological techniques. METHODS Male Wistar rats (n=22) were subjected to 60 minutes MCA occlusion. MR images (T2- and T2*-weighted) were obtained weekly between weeks 1 and… CONTINUE READING

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