MRI correlates of cognitive impairment in childhood-onset multiple sclerosis.

  title={MRI correlates of cognitive impairment in childhood-onset multiple sclerosis.},
  author={Christine Till and R. Ghassemi and B{\'e}reng{\`e}re Aubert-Broche and A Kerbrat and D. Louis Collins and Sridar Narayanan and Douglas L. Arnold and Mary Desrocher and John G. Sled and Brenda L. Banwell},
  volume={25 3},
OBJECTIVE Brain MRI measures were correlated with neuropsychological function in 35 pediatric-onset multiple sclerosis (MS) patients and 33 age- and sex-matched healthy controls. METHOD Mean age of MS patients was 16.3 ± 2.3 years with average disease duration of 4.3 ± 3.1 years. Cortical gray matter, thalamic, and global brain volumes were calculated for all participants using a scaling factor computed using normalization of atrophy method to normalize total and regional brain volumes for… CONTINUE READING


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