MRI contrast variation of thermosensitive magnetoliposomes triggered by focused ultrasound: a tool for image-guided local drug delivery.

@article{Lorenzato2013MRICV,
  title={MRI contrast variation of thermosensitive magnetoliposomes triggered by focused ultrasound: a tool for image-guided local drug delivery.},
  author={Cyril Lorenzato and Alexandru Cernicanu and Marie-Edith Meyre and Matthieu Germain and Agn{\'e}s Pottier and Laurent L{\'e}vy and Baudouin Denis de Senneville and C. Bos and Chrit Moonen and Pierre Smirnov},
  journal={Contrast media & molecular imaging},
  year={2013},
  volume={8 2},
  pages={185-92}
}
Improved drug delivery control during chemotherapy has the potential to increase the therapeutic index. MRI contrast agent such as iron oxide nanoparticles can be co-encapsulated with drugs in nanocarrier liposomes allowing their tracking and/or visualization by MRI. Furthermore, the combination of a thermosensitive liposomal formulation with an external source of heat such as high intensity focused ultrasound guided by MR temperature mapping allows the controlled local release of the content… CONTINUE READING