MRI characteristics of early PML-IRIS after natalizumab treatment in patients with MS.

@article{Wattjes2016MRICO,
  title={MRI characteristics of early PML-IRIS after natalizumab treatment in patients with MS.},
  author={Mike P. Wattjes and Martijn T. Wijburg and Anke Vennegoor and Birgit I. Witte and Marlieke L. de Vos and Nancy D. Richert and Bernard M. J. Uitdehaag and Frederik Barkhof and Joep Killestein},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2016},
  volume={87 8},
  pages={879-84}
}
OBJECTIVE The early detection of MRI findings suggestive of immune reconstitution inflammatory syndrome (IRIS) in natalizumab-associated progressive multifocal leukoencephalopathy (PML) is of crucial clinical relevance in terms of treatment decision-making and clinical outcome. The aim of this study was to investigate the earliest imaging characteristics of PML-IRIS manifestation in natalizumab-treated patients with multiple sclerosis and describe an imaging pattern that might aid in the early… CONTINUE READING