MRI-based monitoring of inflammation and tissue damage in acute and chronic relapsing EAE.

@article{Rausch2003MRIbasedMO,
  title={MRI-based monitoring of inflammation and tissue damage in acute and chronic relapsing EAE.},
  author={Martin Rausch and Peter C Hiestand and Diana R Baumann and Catherine Cannet and Markus Rudin},
  journal={Magnetic resonance in medicine},
  year={2003},
  volume={50 2},
  pages={309-14}
}
Experimental autoimmune encephalomyelitis (EAE) is a commonly used animal model that in several respects mimics human multiple sclerosis (MS), and can be used to design or validate new strategies for treatment of this disease. In the present study, different MRI techniques (macrophage tracking based on labeling cells in vivo by ultrasmall particles of iron oxide (USPIO), blood-brain barrier (BBB) breakdown, and magnetization transfer imaging (MTI)), as well as immunohistological staining were… CONTINUE READING
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