MRI-based characterization of vascular disruption by 5,6-dimethylxanthenone-acetic acid in gliomas.

@article{Seshadri2009MRIbasedCO,
  title={MRI-based characterization of vascular disruption by 5,6-dimethylxanthenone-acetic acid in gliomas.},
  author={Mukund Seshadri and Michael J Ciesielski},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2009},
  volume={29 8},
  pages={1373-82}
}
The well-vascularized nature of gliomas has generated a lot of interest in antiangiogenic therapies. However, the potential of vascular disrupting agents (VDAs) against gliomas has not been investigated extensively. In this study, we examined the in vivo efficacy of the tumor-VDA 5,6-dimethylxanthenone-4-acetic acid (DMXAA) against gliomas. Contrast-enhanced magnetic resonance imaging (MRI) and diffusion-weighted MRI were used to characterize the vascular and cellular responses of GL261 and U87… CONTINUE READING

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