MRI and MRS of the human brain at magnetic fields of 14T to 20T: Technical feasibility, safety, and neuroscience horizons

  title={MRI and MRS of the human brain at magnetic fields of 14T to 20T: Technical feasibility, safety, and neuroscience horizons},
  author={Thomas Budinger and Mark D. Bird},

Pros and cons of ultra-high-field MRI/MRS for human application.

Advances in magnetic resonance tomography

Quantitative magnetic resonance imaging of brain anatomy and in vivo histology

Advances in concepts, instrumentation, biophysical models and validation approaches facilitating this rapidly developing field are discussed, pointing out challenges and the latest advances in this field.

Neuroimaging at 7 T: are we ready for clinical transition?

Some of the challenges related to the clinical use of 7-T scanners and the strengths and weaknesses of clinical imaging at UHF are discussed.

MRI with ultrahigh field strength and high-performance gradients: challenges and opportunities for clinical neuroimaging at 7 T and beyond

An overview of the technical advantages and challenges of performing clinical neuroimaging studies at ultrahigh magnetic field strength combined with ultrahigh and ultrafast gradient technology is provided.

An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems

The combination of multinuclear MR and PET in brain tumour models with specific genetic mutations will enable the physiological background of signal alterations to be explored and the identification of the optimal combination of imaging parameters for the non-invasive characterisation of the molecular profile of tumours.

7 Tesla and Beyond

The advantages but also the challenges of UHF as well as promising advanced methodological developments and clinical applications that particularly benefit from UHF are discussed in this review article.

Safety evaluation of mice exposed to 7.0–33.0 T high‐static magnetic fields

Exposure to 7.0–33.0 T SMF‐exposed mice for 1 h did not have detrimental effects on normal adult mice and most indicators did not show statistically significant changes or were still within the normal ranges, with only a few exceptions.



Toward 20 T magnetic resonance for human brain studies: opportunities for discovery and neuroscience rationale

Twelve neuroscience opportunities are presented as well as an analysis of the biophysical and physiological effects to be investigated before exposing human subjects to the high fields of 14 T and beyond.

Functional mapping in the human brain using high magnetic fields.

It is demonstrated that high magnetic fields result in improved contrast and, more importantly, in elevated sensitivity to capillary level changes coupled to neuronal activity in the blood oxygenation level dependent (BOLD) contrast mechanism used in fMRI.

Contributions to magnetic susceptibility of brain tissue

An interesting aspect of magnetic susceptibility contrast is its sensitivity to the microscopic distribution of iron and myelin, which provides opportunities to extract information at spatial scales well below MRI resolution.

In vivo detection of serine in the human brain by proton magnetic resonance spectroscopy (1H‐MRS) at 7 Tesla

A single‐voxel proton magnetic resonance spectroscopy (1H‐MRS) filtering strategy for in vivo detection of serine (Ser) in human brain at 7T is proposed and the Ser‐to‐Cr concentration ratio for the frontal cortex of healthy adults was estimated to be 0.8 ± 0.2.

Clinical applications at ultrahigh field (7  T). Where does it make the difference?

Although neuro‐ and musculoskeletal imaging have already demonstrated the clinical superiority of ultrahigh fields, whole‐body clinical applications at 7 T are still limited, mainly because of the lack of suitable coils.

Metabolic properties in stroked rats revealed by relaxation-enhanced magnetic resonance spectroscopy at ultrahigh fields.

An enabling relaxation-enhanced MRS approach is demonstrated that by combining highly selective spectral excitations with operation at very high magnetic fields, delivers spectra exhibiting signal-to-noise ratios >50:1 in under 6 s for ~5 × 5 × 5 (mm)(3) voxels, with flat baselines and no interference from water.

MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST)

It is shown that glycogen can be detected indirectly through the water signal by using selective radio frequency (RF) saturation of the hydroxyl protons in the 0.5- to 1.