MRI T2 hypointensity of the dentate nucleus is related to ambulatory impairment in multiple sclerosis

@article{Tjoa2005MRITH,
  title={MRI T2 hypointensity of the dentate nucleus is related to ambulatory impairment in multiple sclerosis},
  author={Christopher W. Tjoa and Ralph H. B. Benedict and Bianca Weinstock-Guttman and Andrew J Fabiano and Rohit Bakshi},
  journal={Journal of the Neurological Sciences},
  year={2005},
  volume={234},
  pages={17-24}
}
OBJECTIVES MRI T2 hypointensity in multiple sclerosis (MS) gray matter, suggesting iron deposition, is associated with physical disability, disease course, lesion load, and brain atrophy. Ambulatory dysfunction limits quality of life; however correlation with conventional MRI remains poor. METHODS Normalized intensity on T2-weighted images was obtained in the basal ganglia, thalamus, red nucleus, and dentate nucleus in 47 MS patients and 15 healthy controls. Brain T1-hypointense and FLAIR… CONTINUE READING

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