MRI Overestimates Excitotoxic Amygdala Lesion Damage in Rhesus Monkeys

@article{Basile2017MRIOE,
  title={MRI Overestimates Excitotoxic Amygdala Lesion Damage in Rhesus Monkeys},
  author={Benjamin M. Basile and Chloe Karaskiewicz and Emily C Fiuzat and Ludise Malkova and Elisabeth A. Murray},
  journal={Frontiers in Integrative Neuroscience},
  year={2017},
  volume={11}
}
Selective, fiber-sparing excitotoxic lesions are a state-of-the-art tool for determining the causal contributions of different brain areas to behavior. For nonhuman primates especially, it is advantageous to keep subjects with high-quality lesions alive and contributing to science for many years. However, this requires the ability to estimate lesion extent accurately. Previous research has shown that in vivo T2-weighted magnetic resonance imaging (MRI) accurately estimates damage following… 

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References

SHOWING 1-10 OF 40 REFERENCES
Assessment of locus and extent of neurotoxic lesions in monkeys using neuroimaging techniques: a replication
MRI‐based evaluation of locus and extent of neurotoxic lesions in monkeys
TLDR
An MRI‐based method to determine the efficacy of injections of the excitotoxin ibotenic acid soon after surgery provided an accurate in vivo evaluation of the locus and extent of neurotoxic lesions and assessed the relationship between neuronal damage and volume reduction.
Object Recognition and Location Memory in Monkeys with Excitotoxic Lesions of the Amygdala and Hippocampus
TLDR
A significant positive correlation between the percentage of damage to the hippocampus and scores on portions of the recognition performance test, suggesting that, paradoxically, the greater the hippocampal damage, the better the recognition.
Selective hippocampal damage in rhesus monkeys impairs spatial memory in an open‐field test
TLDR
A spatial memory task in which rhesus monkeys moved about freely in a large room, on a tether, indicated that they did encode the rewarded location with respect to allocentric landmarks; however, both groups of monkeys were significantly worse at relocating the food when required to approach from a different location.
Distinct contributions of the amygdala and hippocampus to fear expression
TLDR
Data show that the hippocampus and amygdala contribute independently to the overall expression of defensive responses, and both operated groups showed shorter food‐retrieval latencies and exhibited fewer defensive and more approach behaviors when exposed to the fear‐provoking stimuli.
Excitotoxic Lesions of the Amygdala Fail to Produce Impairment in Visual Learning for Auditory Secondary Reinforcement But Interfere with Reinforcer Devaluation Effects in Rhesus Monkeys
TLDR
The results are consistent with the idea that the amygdala is necessary for learning the association between stimuli and the value of particular food rewards; however, it is not necessary for maintaining thevalue of secondary reinforcers, once they have been learned.
Effects of aspiration versus neurotoxic lesions of the amygdala on emotional responses in monkeys
TLDR
It is convincingly demonstrate that the amygdala is crucial for the normal regulation of emotions in monkeys and that the emotional disorders described earlier after amygdalectomy in monkeys were likely exacerbated by the attendant fibre damage.
A combined MRI and histology atlas of the rhesus monkey brain in stereotaxic coordinates
The second edition of this atlas maps the detailed architectonic subdivisions of the cortical and subcortical areas in the macaque monkey brain using high-resolution magnetic resonance (MR) images
Object and spatial memory after neonatal perirhinal lesions in monkeys
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