MRI-Based evaluation of locus and extent of neurotoxic lesions in monkeys.

@article{Mlkov2001MRIBasedEO,
  title={MRI-Based evaluation of locus and extent of neurotoxic lesions in monkeys.},
  author={Ludise M{\'a}lkov{\'a} and Carolyn K Lex and Mortimer Mishkin and Richard C. Saunders},
  journal={Hippocampus},
  year={2001},
  volume={11 4},
  pages={361-70}
}
To minimize the variability in the extent of lesions made by injections of the excitotoxin ibotenic acid in rhesus monkeys, we developed and validated an MRI-based method to determine the efficacy of the injections soon after surgery. T2-weighted MR images were obtained 6-11 days after surgery from 17 brain hemispheres of monkeys that had received bilateral lesions of either the hippocampal formation (HF), perirhinal cortex, or parahippocampal cortex. The extent of lesion estimated from the… CONTINUE READING
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