MRE11 is required for homologous synapsis and DSB processing in rice meiosis

@article{Ji2013MRE11IR,
  title={MRE11 is required for homologous synapsis and DSB processing in rice meiosis},
  author={Jianhui Ji and Ding Tang and Mo Wang and Yafei Li and Lei Zhang and Kejian Wang and Ming Li and Zhukuan Cheng},
  journal={Chromosoma},
  year={2013},
  volume={122},
  pages={363-376}
}
Mre11, a conserved protein found in organisms ranging from yeast to multicellular organisms, is required for normal meiotic recombination. Mre11 interacts with Rad50 and Nbs1/Xrs2 to form a complex (MRN/X) that participates in double-strand break (DSB) ends processing. In this study, we silenced the MRE11 gene in rice and detailed its function using molecular and cytological methods. The OsMRE11-deficient plants exhibited normal vegetative growth but could not set seed. Cytological analysis… Expand
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References

SHOWING 1-10 OF 65 REFERENCES
The role of OsCOM1 in homologous chromosome synapsis and recombination in rice meiosis.
TLDR
Direct evidence for the functions of OsCOM1 in promoting homologous synapsis and recombination in rice meiosis is provided, and several key meiotic proteins were not loaded normally onto chromosomes in Oscom1 mutants. Expand
Mre11 Deficiency in Arabidopsis Is Associated with Chromosomal Instability in Somatic Cells and Spo11-Dependent Genome Fragmentation during Meiosis
TLDR
The fragmentation was substantially suppressed in mre11 spo11-1 double mutants, indicating that Mre11 is required for repair but not for the induction of Spo11-dependent meiotic DNA breaks in Arabidopsis. Expand
Cytological analysis of MRE11 protein during early meiotic prophase I in Arabidopsis and tomato
TLDR
The cytological behavior of a possible EN component, MRE11, a protein that is important for the repair of the numerous, programmed deoxyribonucleic acid double-strand breaks (DSBs) that occur early in the meiotic prophase is described. Expand
The multiple roles of the Mre11 complex for meiotic recombination
  • V. Borde
  • Biology, Medicine
  • Chromosome Research
  • 2007
TLDR
The meiotic phenotypes of several animal models that have been developed to model hypomorphic mutations of the Mre11 complex, involved in humans in some genetic instability disorders are described. Expand
PAIR2 is essential for homologous chromosome synapsis in rice meiosis I
TLDR
This study provides the first description of AE-associated protein in monocot plants and indicates that PAIR2 plays an essential role in promoting homologous chromosome synapsis, but does not play a role in AE formation, sister chromatid cohesion at centromeres or kinetochore assembly in meiosis I of rice. Expand
Meiotic defects in the Arabidopsis rad50 mutant point to conservation of the MRX complex function in early stages of meiotic recombination
TLDR
Both male and female gametogenesis are defective in the Arabidopsis atrad50 mutant and cytological observation of male meiosis indicates that in the absence of the AtRad50 protein, homologous chromosomes are unable to synapse, which supports a role for theArabidopsis MRX complex in early stages of meiotic recombination. Expand
Meiotic recombination proteins localize to linear elements in Schizosaccharomyces pombe
TLDR
It is proposed that LinEs form around designated recombination sites before the induction of DSBs and that most, if not all, meiotic recombination initiates within the setting provided by LinEs. Expand
Asy1, a protein required for meiotic chromosome synapsis, localizes to axis-associated chromatin in Arabidopsis and Brassica
TLDR
Immunogold labelling in conjunction with electron microscopy established that Asy1 localizes to regions of chromatin that associate with the axial/lateral elements of meiotic chromosomes rather than being a component of the synaptonemal complex itself. Expand
The Arabidopsis homologue of Xrcc3 plays an essential role in meiosis
TLDR
An essential role for AtXrcc3 in meiosis in plants and possibly in other higher eukaryotes is shown, supporting the involvement of this Arabidopsis Rad51‐like protein in recombinational repair. Expand
OsSPO11-1 is essential for both homologous chromosome pairing and crossover formation in rice
TLDR
OsSPO11-1 is essential for both homologous chromosomes pairing and crossover formation during meiosis in rice, implying that SC formation is disturbed severely. Expand
...
1
2
3
4
5
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