MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer.

  title={MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer.},
  author={Ananya Sinha Choudhury and L. D. Nelson and Mark T. W. Teo and Sameer Chilka and Selina Bhattarai and Colin Fredrick Johnston and Faye Elliott and Johanna Lowery and Claire Fraser Taylor and Michael Churchman and Johanne Bentley and Margaret A Knowles and Patricia M Harnden and Robert G. Bristow and D Timothy Bishop and Anne E Kiltie},
  journal={Cancer research},
  volume={70 18},
Radical radiotherapy and surgery achieve similar cure rates in muscle-invasive bladder cancer, but the choice of which treatment would be most beneficial cannot currently be predicted for individual patients. The primary aim of this study was to assess whether expression of any of a panel of DNA damage signaling proteins in tumor samples taken before irradiation could be used as a predictive marker of radiotherapy response, or rather was prognostic. Protein expression of MRE11, RAD50, NBS1, ATM… CONTINUE READING


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